CTSAs are a prime example of a complex ecology. Case study methodologies (Yin and Stake) and the Success Case Method (Brinkerhoff) are key approaches to exploring in depth and detail how the CTSA infrastructure supports improvement in clinical and translational research. In particular, it offers opportunities to investigate the relationships necessary for researchers to achieve successful outcomes. Case studies are also flexible and responsive to changing needs of the evaluation. This presentation provides examples from the University of Illinois at Chicago Center for Clinical and Translational Science (UIC CCTS) of how case studies are used to support tracking and evaluation activities.#CTSA #SuccessCaseMethod