Questions regarding biomedical research portfolios often arise from a variety of audiences, both internal and external. With increasing amounts of administrative, output, and outcome data linked to funded projects, the development of tools to analyze large data aggregations in a standardized manner for analysis and evaluation purposes has become critical. Traditional sources of data on funded projects such as yearly progress reports can be limited in timeliness, scope, and ability to be easily summarized across years, thus not adequately addressing common needs of those seeking to evaluate biomedical research portfolios. The presentations from the National Cancer Institute (NCI), the National Institute of General Medical Sciences (NIGMS), and the National Institutes of Health (NIH) will address the full scope of development of analysis tools for biomedical research portfolios, from initial needs assessment to determine the questions of interest through deployment of enterprise systems available to the public, including lessons learned throughout.#eval14 #2014Conference